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History of suicidal ideation or severe depression requires careful evaluation, as GLP-1 medications are not recommended for patients with active mental health crises
Tirzepatide (Zepbound/Mounjaro) is a dual GLP-1/GIP agonist, which explains its edge on weight loss
This hormone works on parts of the brain tied to feeling full and controlling hunger
Conversely, excessive NADPH accumulation can induce reductive stress, leading to the upregulation of NADPH oxidase 4 through activation of the PI3K/Akt signaling pathway, thereby promoting ROS generation, as observed in osteoarthritis (96)
Exendin-4 also reduced vascular immunoglobulin G extravasation, indicating reduced endothelial leakage in the late inflammatory response to ischemia [71]
